|Other Accession||NP_001597.2, NP_997698.1, 20, 11305 (mouse), 79248 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||269873 Da|
|Other Names||ATP-binding cassette sub-family A member 2, ATP-binding cassette transporter 2, ATP-binding cassette 2, ABCA2, ABC2, KIAA1062|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCA2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Forms discrete, punctate intracellular vesicles|
|Tissue Location||Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001597.2; NP_997698.1).
ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease Macé S, Cousin E, Ricard S, Génin E, Spanakis E, Lafargue-Soubigou C, Génin B, Fournel R, Roche S, Haussy G, Massey F, Soubigou S, Bréfort G, Benoit P, Brice A, Campion D, Hollis M, Pradier L, Benavides J, Deleuze JF Neurobiol Dis. 2005 Feb;18(1):119-25 PMID: 15649702
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