|Other Accession||NP_000341.2, 24|
|Calculated MW||255944 Da|
|Other Names||Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein, ABCA4, ABCR|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCA4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.|
|Cellular Location||Membrane; Multi-pass membrane protein Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor|
|Tissue Location||Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy Singh HP, Jalali S, Hejtmancik JF, Kannabiran C Am J Ophthalmol. 2006 May;141(5):906-13 PMID: 16546111
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