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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > ABCA4 Antibody (C-Term)
ABCA4 Antibody (C-Term)
Peptide-affinity purified goat antibody
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Application 
| E |
|---|---|
| Primary Accession | P78363 |
| Other Accession | NP_000341.2, 24 |
| Predicted | Human, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 255944 Da |
| Gene ID | 24 |
|---|---|
| Other Names | Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein, ABCA4, ABCR |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ABCA4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCA4 (HGNC:34) |
|---|---|
| Function | Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11- cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene- phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all- trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans- retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid (PubMed:24097981, PubMed:22735453, PubMed:23144455, PubMed:20404325, PubMed:10075733, PubMed:29847635, PubMed:33375396). May display both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N- retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene- phosphatidylethanolamine (By similarity). |
| Cellular Location | Membrane; Multi- pass membrane protein. Endoplasmic reticulum. Cytoplasmic vesicle. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:F1MWM0}. Note=Localized to the rim and incisures of rod outer segments disks. {ECO:0000250|UniProtKB:F1MWM0} |
| Tissue Location | Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy Singh HP, Jalali S, Hejtmancik JF, Kannabiran C Am J Ophthalmol. 2006 May;141(5):906-13 PMID: 16546111
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$ 341.00
Cat# AF2776a
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