|Other Accession||NP_006668.1, 10869|
|Calculated MW||145651 Da|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 19, 22.214.171.124, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19, Zinc finger MYND domain-containing protein 9, USP19, KIAA0891, ZMYND9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||USP19 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
High incidence of ubiquitin-like domains in human ubiquitin-specific proteases. Zhu X, Ménard R, Sulea T. Proteins. 2007 Oct 1;69(1):1-7 PMID: 17597129
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