|Other Accession||NP_036607.3, 27005, 30941 (mouse)|
|Predicted||Human, Mouse, Rat, Cow|
|Calculated MW||62656 Da|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 21, 126.96.36.199, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, USP21, USP23|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||USP21 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001014443.1 NP_036607.3
Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. Gong L, Kamitani T, Millas S, Yeh ET. J Biol Chem. 2000 May 12;275(19):14212-6 PMID: 10799498
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