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USP21 Antibody (N-Term)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UK80
Other Accession NP_036607.3, 27005, 30941 (mouse)
Predicted Human, Mouse, Rat, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 62656 Da
Additional Information
Gene ID 27005
Other Names Ubiquitin carboxyl-terminal hydrolase 21,, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, USP21, USP23
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUSP21 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP21
Synonyms USP23
Function Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
Cellular Location Cytoplasm. Nucleus
Tissue Location Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung
Research Areas
Citations (0)

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Reported variants represent identical protein: NP_001014443.1 NP_036607.3


Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. Gong L, Kamitani T, Millas S, Yeh ET. J Biol Chem. 2000 May 12;275(19):14212-6 PMID: 10799498

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$ 325.00
Cat# AF2787a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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