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USP28 Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • IHC - USP28 Antibody (internal region) AF2788a
    AF2788a (3.8 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q96RU2
Other Accession NP_065937.1, 57646
Reactivity Human
Predicted Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 122491 Da
Additional Information
Gene ID 57646
Other Names Ubiquitin carboxyl-terminal hydrolase 28, 3.4.19.12, Deubiquitinating enzyme 28, Ubiquitin thioesterase 28, Ubiquitin-specific-processing protease 28, USP28, KIAA1515
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUSP28 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP28
Synonyms KIAA1515
Function Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.
Cellular Location Nucleus, nucleoplasm
Research Areas
Citations (0)

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References

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. Popov N, Herold S, Llamazares M, Schülein C, Eilers M. Cell Cycle. 2007 Aug;6(19):2327-31. Epub 2007 Jul 26 PMID: 17873522

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$ 325.00
Cat# AF2788a
Size:
Quantity:
(40 western blots)
Availability: 7-10 days
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