DUBA Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q96G74 |
Other Accession | NP_060072.1, 55593, 54644 (mouse), 363452 (rat) |
Predicted | Human, Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 60626 Da |
Gene ID | 55593 |
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Other Names | OTU domain-containing protein 5, 3.4.19.12, Deubiquitinating enzyme A, DUBA, OTUD5 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DUBA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OTUD5 (HGNC:25402) |
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Function | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
References
DUBA: a deubiquitinase that regulates type I interferon production. Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. Science. 2007 Dec 7;318(5856):1628-32. Epub 2007 Nov 8 PMID: 17991829
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