|Other Accession||NP_060072.1, 55593, 54644 (mouse), 363452 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||60626 Da|
|Other Names||OTU domain-containing protein 5, 220.127.116.11, Deubiquitinating enzyme A, DUBA, OTUD5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUBA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro).|
|Tissue Location||Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
DUBA: a deubiquitinase that regulates type I interferon production. Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. Science. 2007 Dec 7;318(5856):1628-32. Epub 2007 Nov 8 PMID: 17991829
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