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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > ABCB10 Antibody (C-Term)
ABCB10 Antibody (C-Term)
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9NRK6 |
| Other Accession | NP_036221.2, 23456, 56199 (mouse), 361439 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 79148 Da |
| Gene ID | 23456 |
|---|---|
| Other Names | ATP-binding cassette sub-family B member 10, mitochondrial, ATP-binding cassette transporter 10, ABC transporter 10 protein, Mitochondrial ATP-binding cassette 2, M-ABC2, ABCB10 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ABCB10 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCB10 (HGNC:41) |
|---|---|
| Function | Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JI39}; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). Graf SA, Haigh SE, Corson ED, Shirihai OS. J Biol Chem. 2004 Oct 8;279(41):42954-63 PMID: 15215243
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$ 216.00
Cat# AF2793a
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