|Other Accession||NP_150284.1, 94032, 59314 (rat)|
|Calculated MW||8658 Da|
|Other Names||Calcium/calmodulin-dependent protein kinase II inhibitor 2, CaM-KII inhibitory protein, CaM-KIIN, CAMK2N2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAMKIIN Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2.|
|Tissue Location||Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells|
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Provided below are standard protocols that you may find useful for product applications.
Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitor. Sanhueza M, McIntyre CC, Lisman JE. J Neurosci. 2007 May 9;27(19):5190-9. PMID: 17494705
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