|Other Accession||NP_002931.2, NP_001035809.1, 6059, 24015 (mouse), 361390 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||67314 Da|
|Other Names||ATP-binding cassette sub-family E member 1, 2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, ABCE1, RLI, RNASEL1, RNASELI, RNS4I|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCE1 / RNase L Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RLI, RNASEL1, RNASELI, RNS4I|
|Function||Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_002931.2 NP_001035809.1
ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. Shichijo S, Ishihara Y, Azuma K, Komatsu N, Higashimoto N, Ito M, Nakamura T, Ueno T, Harada M, Itoh K. Oncol Rep. 2005 May;13(5):907-13. PMID: 15809757
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