|Application ||WB, E|
|Other Accession||NP_001195.2, 659|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||115201 Da|
|Other Names||Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, 184.108.40.206, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMPR2 Antibody (internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation Beppu H, Mwizerwa ON, Beppu Y, Dattwyler MP, Lauwers GY, Bloch KD, Goldstein AM Oncogene. 2008 Feb 14;27(8):1063-70. Epub 2007 Aug 13 PMID: 17700526
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