|Application ||WB, E|
|Other Accession||NP_001195.2, 659|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||115201 Da|
|Other Names||Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, 22.214.171.124, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMPR2 Antibody (internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart and liver.|
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Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation Beppu H, Mwizerwa ON, Beppu Y, Dattwyler MP, Lauwers GY, Bloch KD, Goldstein AM Oncogene. 2008 Feb 14;27(8):1063-70. Epub 2007 Aug 13 PMID: 17700526
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