|Application ||WB, E|
|Other Accession||NP_066958.2, NP_001006933.1, 6196|
|Predicted||Human, Mouse, Horse|
|Calculated MW||83239 Da|
|Other Names||Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 184.108.40.206, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, pp90RSK3, RPS6KA2, MAPKAPK1C, RSK3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPS6KA2 Antibody (C-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_066958.2; NP_001006933.1)
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J Cancer Cell. 2007 Sep;12(3):201-14 PMID: 17785202
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