|Application ||WB, IHC, E|
|Other Accession||NP_001827.1, 1215|
|Calculated MW||27325 Da|
|Other Names||Chymase, 220.127.116.11, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CMA1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.|
|Cellular Location||Secreted. Cytoplasmic granule. Note=Mast cell granules|
|Tissue Location||Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha Heikkilä HM, Lätti S, Leskinen MJ, Hakala JK, Kovanen PT, Lindstedt KA Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):309-14. Epub 2007 Dec 13 PMID: 18079408
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