|Application ||WB, IHC, E|
|Other Accession||NP_001827.1, 1215|
|Calculated MW||27325 Da|
|Other Names||Chymase, 188.8.131.52, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CMA1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.|
|Cellular Location||Secreted. Cytoplasmic granule. Note=Mast cell granules|
|Tissue Location||Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions|
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Provided below are standard protocols that you may find useful for product applications.
Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha Heikkilä HM, Lätti S, Leskinen MJ, Hakala JK, Kovanen PT, Lindstedt KA Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):309-14. Epub 2007 Dec 13 PMID: 18079408
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