|Application ||WB, E|
|Other Accession||NP_002560.1, 5045|
|Calculated MW||86678 Da|
|Other Names||Furin, 220.127.116.11, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, PACE, PCSK3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FURIN / PCSK3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FUR, PACE, PCSK3|
|Function||Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Single- pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113) Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113).|
|Tissue Location||Seems to be expressed ubiquitously.|
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Hepatic proprotein convertases modulate HDL metabolism Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ Cell Metab. 2007 Aug;6(2):129-36 PMID: 17681148
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