|Application ||WB, E|
|Other Accession||NP_001071643.1, 2030|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||50219 Da|
|Other Names||Equilibrative nucleoside transporter 1, Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter, Equilibrative NBMPR-sensitive nucleoside transporter, Nucleoside transporter, es-type, Solute carrier family 29 member 1, SLC29A1, ENT1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENT1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Predominantly localized in the basolateral membrane in polarized MDCK cells|
|Tissue Location||Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001071642.1, NP_001071645.1, NP_001071644.1, NP_004946.1, NP_001071643.1
High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium Puebla C, Farías M, González M, Vecchiola A, Aguayo C, Krause B, Pastor-Anglada M, Casanello P, Sobrevia L J Cell Physiol. 2008 Jun;215(3):645-56 PMID: 18064606
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