OPRD1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | P41143 |
Other Accession | NP_000902.3, 4985 |
Predicted | Human, Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 40369 Da |
Gene ID | 4985 |
---|---|
Other Names | Delta-type opioid receptor, D-OR-1, DOR-1, OPRD1, OPRD |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | OPRD1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OPRD1 |
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Synonyms | OPRD |
Function | G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. |
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Provided below are standard protocols that you may find useful for product applications.
References
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL Nat Genet. 2000 Jun;25(2):195-200 PMID: 10835636
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