|Other Accession||NP_000902.3, 4985|
|Predicted||Human, Mouse, Rat|
|Calculated MW||40369 Da|
|Other Names||Delta-type opioid receptor, D-OR-1, DOR-1, OPRD1, OPRD|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OPRD1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.|
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Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL Nat Genet. 2000 Jun;25(2):195-200 PMID: 10835636
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