|Application ||IHC, E|
|Other Accession||NP_002209.2, 3700|
|Calculated MW||103357 Da|
|Other Names||Inter-alpha-trypsin inhibitor heavy chain H4, ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP, Plasma kallikrein sensitive glycoprotein 120, Gp120, PK-120, 70 kDa inter-alpha-trypsin inhibitor heavy chain H4, 35 kDa inter-alpha-trypsin inhibitor heavy chain H4, ITIH4, IHRP, ITIHL1, PK120|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITIH4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IHRP, ITIHL1, PK120|
|Function||Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.|
|Tissue Location||Liver specific.|
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Provided below are standard protocols that you may find useful for product applications.
The immunizing peptide represents a region of the 35kDa chain. This chain is glycosylated giving rise to an apparent higher molecular weight.
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, Ressom HW, Rashid A, He AR, Mendelson JS, Jessup JM, Shetty K, Zasloff M, Mishra B, Reddy EP, Johnson L, Mishra L. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50. Epub 2008 Feb 8. PMID: 18263735
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