|Other Accession||NP_004786.2, 9365|
|Calculated MW||116181 Da|
|Other Names||Klotho, 220.127.116.11, Klotho peptide, KL|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Klotho / KL Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide Klotho peptide: Secreted.|
|Tissue Location||Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney|
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Provided below are standard protocols that you may find useful for product applications.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19796-801. Epub 2007 Dec 3. PMID: 18056631
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