|Application ||WB, E|
|Other Accession||NP_057421.1, 51466, 14026 (mouse), 79115 (rat)|
|Calculated MW||44620 Da|
|Other Names||Ena/VASP-like protein, Ena/vasodilator-stimulated phosphoprotein-like, EVL, RNB6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EVL Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T- cells, localizes to the F-actin collar and the distal tip of microspikes (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Filopodia are required for cortical neurite initiation. Dent EW, Kwiatkowski AV, Mebane LM, Philippar U, Barzik M, Rubinson DA, Gupton S, Van Veen JE, Furman C, Zhang J, Alberts AS, Mori S, Gertler FB. Nat Cell Biol. 2007 Dec;9(12):1347-59. Epub 2007 Nov 18. PMID: 18026093
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