|Application ||WB, E|
|Other Accession||NP_003711.1, NP_982257.1, 8624, 56088 (mouse), 288236 (rat)|
|Predicted||Mouse, Rat, Rabbit, Dog, Cow|
|Calculated MW||32854 Da|
|Other Names||Proteasome assembly chaperone 1, PAC-1, Chromosome 21 leucine-rich protein, C21-LRP, Down syndrome critical region protein 2, PSMG1, C21LRP, DSCR2, PAC1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DSCR2 / PSMG1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21LRP, DSCR2, PAC1|
|Function||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum.|
|Tissue Location||In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_003711.1; NP_982257.1.
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Kugathasan S, Baldassano RN, Bradfield JP, Sleiman PM, Imielinski M, Guthery SL, Cucchiara S, Kim CE, Frackelton EC, Annaiah K, Glessner JT, Santa E, Willson T, Eckert AW, Bonkowski E, Shaner JL, Smith RM, Otieno FG, Peterson N, Abrams DJ, Chiavacci RM, G Nat Genet. 2008 Aug 31. PMID: 18758464
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