|Application ||WB, E|
|Other Accession||NP_003237.2, 7057|
|Calculated MW||129383 Da|
|Other Names||Thrombospondin-1, THBS1, TSP, TSP1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Thrombospondin Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).|
|Cellular Location||Endoplasmic reticulum. Sarcoplasmic reticulum|
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The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells. Pan MR, Chang HC, Chuang LY, Hung WC. Exp. Biol. Med. (Maywood) 2008 Apr 233 (4): 456-62. PMID: 18367635
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