|Other Accession||NP_003950.1, 9026|
|Predicted||Human, Pig, Dog, Cow|
|Calculated MW||119388 Da|
|Other Names||Huntingtin-interacting protein 1-related protein, HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R, HIP12, KIAA0655|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HIP1R/ HIP12 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.|
|Cellular Location||Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region|
|Tissue Location||Brain, heart, kidney, pancreas, and liver, but not in lung or placenta|
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Provided below are standard protocols that you may find useful for product applications.
Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly. Poupon V, Girard M, Legendre-Guillemin V, Thomas S, Bourbonniere L, Philie J, Bright NA, McPherson PS, Proc. Natl. Acad. Sci. U.S.A. 2008 Jan 105 (1): 168-73. PMID: 18165318
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