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CXXC4 Antibody (C-Terminus, near)

Peptide-affinity purified goat antibody

     
  • IHC - CXXC4 Antibody (C-Terminus, near) AF2928a
    AF2928a (3.8 µg/ml) staining of paraffin embedded Human Breast. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q9H2H0
Other Accession NP_079488.1, 80319, 319478 (mouse)
Reactivity Human
Predicted Mouse
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Additional Information
Other Names CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein, CXXC4, IDAX
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCXXC4 Antibody (C-Terminus, near) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CXXC4
Synonyms IDAX
Function Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
Cellular Location Cytoplasm. EMBL; AF272159; AAG42072.1; -; mRNA EMBL; AC093628; AAY40933.1; -; Genomic_DNA EMBL; CH471057; EAX06175.1; -; Genomic_DNA EMBL; BC119751; AAI19752.1; -; mRNA EMBL; BC119752; AAI19753.1; -; mRNA UniGene; Hs.12248; - UniGene; Hs.624057; - PDB; 5VC9; X-ray; 2.10 A; C/F=133-180 PDBsum; 5VC9; - ProteinModelPortal; Q9H2H0; - SMR; Q9H2H0; - IntAct; Q9H2H0; 6 STRING; 9606.ENSP00000412267; - iPTMnet; Q9H2H0; - PhosphoSitePlus; Q9H2H0; - DMDM; 74752605; - PaxDb; Q9H2H0; - PRIDE; Q9H2H0; - ProteomicsDB; 80549; - Ensembl; ENST00000426831; ENSP00000412267; ENSG00000168772 DisGeNET; 80319; - GeneCards; CXXC4; - HGNC; HGNC:24593; CXXC4 HPA; HPA036600; - MIM; 611645; gene neXtProt; NX_Q9H2H0; - PharmGKB; PA134992016; - eggNOG; ENOG410IEZT; Eukaryota eggNOG; ENOG4111BB0; LUCA HOGENOM; HOG000112118; - HOVERGEN; HBG107791; - InParanoid; Q9H2H0; - PhylomeDB; Q9H2H0; - TreeFam; TF326617; - Reactome; R-HSA-5368598; Negative regulation of TCF-dependent signaling by DVL-interacting proteins PRO; PR:Q9H2H0; - Proteomes; UP000005640; Unplaced CleanEx; HS_CXXC4; - GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL GO; GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL GO; GO:0003677; F:DNA binding; IEA:InterPro GO; GO:0030165; F:PDZ domain binding; IPI:BHF-UCL GO; GO:0008270; F:zinc ion binding; IEA:InterPro GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:BHF-UCL GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW GO; GO:0007352; P:zygotic specification of dorsal/ventral axis; ISS:BHF-UCL InterPro; IPR002857; Znf_CXXC Pfam; PF02008; zf-CXXC; 1 PROSITE; PS51058; ZF_CXXC; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Reference proteome; Wnt signaling pathway; Zinc; Zinc-finger CHAIN 1 198 CXXC-type zinc finger protein 4 /FTId=PRO_0000317542 ZN_FING 132 173 CXXC-type. {ECO:0000255|PROSITE- ProRule:PRU00509} REGION 161 166 Interaction with DVL1. COMPBIAS 116 123 Poly-Ser HELIX 143 146 {ECO:0000244|PDB:5VC9} HELIX 155 158 {ECO:0000244|PDB:5VC9} HELIX 160 163 {ECO:0000244|PDB:5VC9} TURN 168 170 {ECO:0000244|PDB:5VC9} HELIX 173 175 {ECO:0000244|PDB:5VC9} SEQUENCE 198 AA; 20978 MW; 9D9F7FAD11A9B759 CRC64; MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC GAAEAEIMNL PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD SAFQIANLAD CPQNHSSSSS SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG TSLERTPVPS AEAFRWFF
Research Areas
Citations (0)

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References

Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. Kojima T, Shimazui T, Hinotsu S, Joraku A, Oikawa T, Kawai K, Horie R, Suzuki H, Nagashima R, Yoshikawa K, Michiue T, Asashima M, Akaza H, Uchida K. Oncogene 2008 Oct. [Epub ahead of print] PMID: 18931698

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$ 335.00
Cat# AF2928a
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