|Other Accession||NP_062816.2, NP_001153602.1, NP_001153604.1, NP_1153605.1, NP_001153606.1, 56479, 226922 (mouse), 259273 (rat)|
|Predicted||Human, Mouse, Rat, Pig, Dog|
|Calculated MW||102179 Da|
|Other Names||Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv7.5, KCNQ5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNQ5 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to cross-react with isoform 1, 2, 3, 4 and 5 (NP_062816.2; NP_001153602.1; NP_001153604.1; NP_1153605.1; NP_001153606.1).
Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. Schuetz F, Kumar S, Poronnik P, Adams DJ. Am J Physiol Cell Physiol. 2008 Jul;295(1):C73-80. PMID: 18463232
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