|Other Accession||NP_002079.3, 2901, 24407 (rat)|
|Predicted||Human, Rat, Cow|
|Calculated MW||109265 Da|
|Other Names||Glutamate receptor ionotropic, kainate 5, GluK5, Excitatory amino acid receptor 2, EAA2, Glutamate receptor KA-2, KA2, GRIK5, GRIK2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRIK5 / KA2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes. Fotheringham J, Williams EL, Akhyani N, Jacobson S. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2008 Jun 3 (2): 105-16. PMID: 18247129
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