|Other Accession||NP_116274.3, 84971, 235040 (mouse), 686505 (rat)|
|Predicted||Human, Mouse, Rat, Pig, Dog|
|Calculated MW||52922 Da|
|Other Names||Cysteine protease ATG4D, 3.4.22.-, AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, Cysteine protease ATG4D, mitochondrial, ATG4D, APG4D, AUTL4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATG4D Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.|
|Cellular Location||Cysteine protease ATG4D: Cytoplasm|
|Tissue Location||Mainly expressed in skeletal muscle and, to a lower extent, in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C. The Journal of biological chemistry 2003 Feb 278 (6): 3671-8. PMID: 12446702
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