|Application ||IHC, E|
|Other Accession||NP_001612.1, 196|
|Calculated MW||96147 Da|
|Other Names||Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AHR Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus|
|Tissue Location||Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells Hollingshead BD, Beischlag TV, Dinatale BC, Ramadoss P, Perdew GH Cancer Res. 2008 May 15;68(10):3609-17 PMID: 18483242
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