|Application ||WB, E|
|Other Accession||NP_036576.1, NP_937998.1, 23626|
|Calculated MW||44537 Da|
|Other Names||Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35, SPO11|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPO11 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_036576.1; NP_937998.1)
Mapping meiotic single-strand DNA reveals a new landscape of DNA double-strand breaks in Saccharomyces cerevisiae Buhler C, Borde V, Lichten M PLoS Biol. 2007 Dec;5(12):e324 PMID: 18076285
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