|Application ||WB, E|
|Other Accession||NP_036576.1, NP_937998.1, 23626|
|Calculated MW||44537 Da|
|Other Names||Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35, SPO11|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPO11 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_036576.1; NP_937998.1)
Mapping meiotic single-strand DNA reveals a new landscape of DNA double-strand breaks in Saccharomyces cerevisiae Buhler C, Borde V, Lichten M PLoS Biol. 2007 Dec;5(12):e324 PMID: 18076285
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