|Other Accession||NP_006135.1, 3001|
|Calculated MW||28999 Da|
|Other Names||Granzyme A, 188.8.131.52, CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF, GZMA, CTLA3, HFSP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GZMA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.|
|Cellular Location||Isoform alpha: Secreted. Cytoplasmic granule|
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Provided below are standard protocols that you may find useful for product applications.
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J, Cell 2008 May 133 (4): 681-92. PMID: 18485875
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