|Application ||WB, IHC, E|
|Other Accession||NP_001090.2, 55, 56318 (mouse), 56780 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||44566 Da|
|Other Names||Prostatic acid phosphatase, PAP, 126.96.36.199, 5'-nucleotidase, 5'-NT, 188.8.131.52, Ecto-5'-nucleotidase, Thiamine monophosphatase, TMPase, PAPf39, ACPP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACPP Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.|
|Cellular Location||Isoform 1: Secreted.|
|Tissue Location||Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both isoforms (NP_001090.2; NP_001127666.1).
Prostatic acid phosphatase is not a prostate specific target. Quintero IB, Araujo CL, Pulkka AE, Wirkkala RS, Herrala AM, Eskelinen EL, Jokitalo E, Hellström PA, Tuominen HJ, Hirvikoski PP, Vihko PT. Cancer research 2007 Jul 67 (14): 6549-54. PMID: 17638863
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