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MOZ / KAT6A Antibody (Internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q92794 |
| Other Accession | NP_006757.2, 7994 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 225028 Da |
| Gene ID | 7994 |
|---|---|
| Other Names | Histone acetyltransferase KAT6A, 2.3.1.48, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, MYST-3, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2, Zinc finger protein 220, KAT6A, MOZ, MYST3, RUNXBP2, ZNF220 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOZ / KAT6A Antibody (Internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KAT6A |
|---|---|
| Synonyms | MOZ, MYST3, RUNXBP2, ZNF220 |
| Function | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. |
| Cellular Location | Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants NP_001092882.1, NP_006757.2, NP_001092883.1 represent identical protein.
References
Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest. Rokudai S, Aikawa Y, Tagata Y, Tsuchida N, Taya Y, Kitabayashi I. J Biol Chem. 2009 Jan 2;284(1):237-44. PMID: 19001415
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