|Other Accession||NP_055925.2, 23137, 226026 (mouse), 293967 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||128806 Da|
|Other Names||Structural maintenance of chromosomes protein 5, SMC protein 5, SMC-5, hSMC5, SMC5, KIAA0594, SMC5L1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMC5 Antibody (Internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6.|
|Cellular Location||Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. Pebernard S, Perry JJ, Tainer JA, Boddy MN. Mol Biol Cell. 2008 Oct;19(10):4099-109. PMID: 18667531
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