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SMC5 Antibody (Internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IY18
Other Accession NP_055925.2, 23137, 226026 (mouse), 293967 (rat)
Predicted Human, Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 128806 Da
Additional Information
Gene ID 23137
Other Names Structural maintenance of chromosomes protein 5, SMC protein 5, SMC-5, hSMC5, SMC5, KIAA0594, SMC5L1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSMC5 Antibody (Internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMC5
Synonyms KIAA0594, SMC5L1
Function Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6.
Cellular Location Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. Pebernard S, Perry JJ, Tainer JA, Boddy MN. Mol Biol Cell. 2008 Oct;19(10):4099-109. PMID: 18667531

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$ 325.00
Cat# AF2971a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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