|Application ||WB, E|
|Other Accession||NP_001108.2, 116, 11516 (mouse), 24166 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||18835 Da|
|Other Names||Pituitary adenylate cyclase-activating polypeptide, PACAP, PACAP-related peptide, PRP-48, Pituitary adenylate cyclase-activating polypeptide 27, PACAP-27, PACAP27, Pituitary adenylate cyclase-activating polypeptide 38, PACAP-38, PACAP38, ADCYAP1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PACAP Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001093203.1, NP_001108.2.
Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Bourgault S, Vaudry D, Botia B, Couvineau A, Laburthe M, Vaudry H, Fournier A. Peptides 2008 Jun 29 (6): 919-32. PMID: 18353507
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