|Other Accession||NP_998734.1, NP_001166955.1, 10529, 74103 (mouse)|
|Predicted||Human, Mouse, Dog|
|Calculated MW||116453 Da|
|Other Names||Nebulette, Actin-binding Z-disk protein, NEBL, LNEBL|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NEBL / nebulette Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.|
|Cellular Location||Isoform 2: Cytoplasm|
|Tissue Location||Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 2 and isoform 3 (NP_998734.1; NP_001166955.1) only, but does not recognize isoform 1 (NP_006384.1).
The nebulette repeat domain is necessary for proper maintenance of tropomyosin with the cardiac sarcomere. Bonzo JR, Norris AA, Esham M, Moncman CL, Exp Cell Res. 2008 Nov 15;314(19):3519-30. Epub 2008 Sep 16. PMID: 18823973
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