|Other Accession||NP_005577.1, 4188|
|Calculated MW||25029 Da|
|Other Names||MyoD family inhibitor, Myogenic repressor I-mf, MDFI|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MDFI Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
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Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1. Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L, The Journal of biological chemistry 2003 Dec 278 (52): 52763-72. PMID: 14530267
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