|Application ||WB, IHC, E|
|Other Accession||NP_004127.1, 3658, 64602 (mouse), 64831 (rat)|
|Calculated MW||105045 Da|
|Other Names||Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2, IREB2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IREB2 / IRP2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.|
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Provided below are standard protocols that you may find useful for product applications.
Excess capacity of the iron regulatory protein system. Wang W, Di X, D'Agostino RB, Torti SV, Torti FM, The Journal of biological chemistry 2007 Aug 282 (34): 24650-9. PMID: 17604281
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