Talin 1 / TLN1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9Y490 |
Other Accession | NP_006280.3, 7094, 21894 (mouse), 313494 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 269767 Da |
Gene ID | 7094 |
---|---|
Other Names | Talin-1, TLN1, KIAA1027, TLN |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Talin 1 / TLN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TLN1 |
---|---|
Synonyms | KIAA1027, TLN |
Function | High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). |
Cellular Location | Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). |
Tissue Location | [Isoform 2]: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is not expected to cross-react with the highly similar protein Talin 2.
References
Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. Manevich E, Grabovsky V, Feigelson SW, Alon R, The Journal of biological chemistry 2007 Aug 282 (35): 25338-48. PMID: 17597073
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