|Application ||WB, E|
|Other Accession||NP_006280.3, 7094, 21894 (mouse), 313494 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||269767 Da|
|Other Names||Talin-1, TLN1, KIAA1027, TLN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Talin 1 / TLN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).|
|Cellular Location||Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody is not expected to cross-react with the highly similar protein Talin 2.
Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. Manevich E, Grabovsky V, Feigelson SW, Alon R, The Journal of biological chemistry 2007 Aug 282 (35): 25338-48. PMID: 17597073
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.