|Application ||WB, E|
|Other Accession||NP_006280.3, 7094, 21894 (mouse), 313494 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||269767 Da|
|Other Names||Talin-1, TLN1, KIAA1027, TLN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Talin 1 / TLN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).|
|Cellular Location||Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is not expected to cross-react with the highly similar protein Talin 2.
Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. Manevich E, Grabovsky V, Feigelson SW, Alon R, The Journal of biological chemistry 2007 Aug 282 (35): 25338-48. PMID: 17597073
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