|Application ||WB, E|
|Other Accession||NP_003861.1, 8826, 29875 (mouse), 361598 (rat)|
|Calculated MW||189252 Da|
|Other Names||Ras GTPase-activating-like protein IQGAP1, p195, IQGAP1, KIAA0051|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IQGAP1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.|
|Cellular Location||Cell membrane.|
|Tissue Location||Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. Ren JG, Li Z, Sacks DB, The Journal of biological chemistry 2008 Aug 283 (34): 22972-82. PMID: 18567582
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