|Other Accession||NP_620714.2, 219931|
|Calculated MW||85243 Da|
|Other Names||Two pore calcium channel protein 2, Voltage-dependent calcium channel protein TPC2, TPCN2, TPC2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPCN2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein. Note=Only the acidic lysosomal fraction is sensitive to NAADP.|
|Tissue Location||Widely expressed. Expressed at high level in liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
NAADP mobilizes calcium from acidic organelles through two-pore channels. Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX. Nature 2009 May 459 (7246): 596-600. PMID: 19387438
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