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UBR4 / ZUBR1 Antibody (C-Term)

Peptide-affinity purified goat antibody

  • IHC - UBR4 / ZUBR1 Antibody (C-Term) AF3012a
    AF3012a (5 µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5T4S7
Other Accession NP_065816.2, 23352, 69116 (mouse), 313658 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 573841 Da
Additional Information
Gene ID 23352
Other Names E3 ubiquitin-protein ligase UBR4, 6.3.2.-, 600 kDa retinoblastoma protein-associated factor, N-recognin-4, Retinoblastoma-associated factor of 600 kDa, RBAF600, p600, Zinc finger UBR1-type protein 1, UBR4, KIAA0462, KIAA1307, RBAF600, ZUBR1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUBR4 / ZUBR1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBR4
Synonyms KIAA0462, KIAA1307, RBAF600, ZUBR1
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Cellular Location Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility
Research Areas
Citations (0)

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The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Lennerz V, Fatho M, Gentilini C, Frye RA, Lifke A, Ferel D, Wölfel C, Huber C, Wölfel T. Proceedings of the National Academy of Sciences of the United States of America 2005 Nov 102 (44): 16013-8. PMID: 16247014

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$ 325.00
Cat# AF3012a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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