|Other Accession||NP_000323.2, 6310|
|Predicted||Human, Pig, Dog|
|Calculated MW||86923 Da|
|Other Names||Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATXN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity).|
|Cellular Location||Cytoplasm. Nucleus Note=Colocalizes with USP7 in the nucleus|
|Tissue Location||Widely expressed throughout the body.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Reported variant NP_000323.2 and NP_001121636.1 represent identical protein.
Identification and characterization of the gene causing type 1 spinocerebellar ataxia Banfi S, Servadio A, Chung MY, Kwiatkowski TJ Jr, McCall AE, Duvick LA, Shen Y, Roth EJ, Orr HT, Zoghbi HY Nat. Genet. 1994 Aug 7 (4): 513-20 PMID: 7951322
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