SRCAP Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q6ZRS2 |
Other Accession | NP_006653.2, 10847, 100043597 (mouse), 361652 (rat) |
Predicted | Human, Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 343555 Da |
Gene ID | 10847 |
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Other Names | Helicase SRCAP, 3.6.4.-, Domino homolog 2, Snf2-related CBP activator, SRCAP, KIAA0309 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SRCAP Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SRCAP |
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Synonyms | KIAA0309 |
Function | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch- mediated transcription. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:10702287} |
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Provided below are standard protocols that you may find useful for product applications.
References
The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. Wong MM, Cox LK, Chrivia JC. The Journal of biological chemistry 2007 Sep 282 (36): 26132-9. PMID: 17617668
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