|Other Accession||NP_062818.1, 28234, 28253 (mouse)|
|Predicted||Human, Mouse, Dog|
|Calculated MW||77403 Da|
|Other Names||Solute carrier organic anion transporter family member 1B3, Liver-specific organic anion transporter 2, LST-2, Organic anion transporter 8, Organic anion-transporting polypeptide 8, OATP-8, Solute carrier family 21 member 8, SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLCO1B3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LST2, OATP1B3, OATP8, SLC21A8|
|Function||Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder|
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Provided below are standard protocols that you may find useful for product applications.
Impact of regulatory polymorphisms in organic anion transporter genes in the human liver. Aoki M, Terada T, Ogasawara K, Katsura T, Hatano E, Ikai I, Inui K, Pharmacogenetics and genomics 2009 Aug 19 (8): 647-56. PMID: 19620935
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