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Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9ULG1 |
| Other Accession | NP_060023.1, 54617, 296084 (rat) |
| Predicted | Human, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 176753 Da |
| Gene ID | 54617 |
|---|---|
| Other Names | DNA helicase INO80, hINO80, 3.6.4.12, INO80 complex subunit A, Putative DNA helicase INO80 complex homolog 1, INO80, INO80A, INOC1, KIAA1259 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INO80 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INO80 |
|---|---|
| Synonyms | INO80A, INOC1, KIAA1259 |
| Function | DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00746, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20971067} Note=Colocalizes with PCNA at replication forks during S-phase Recruited to DNA damage sites in a ACTR8-dependent manner |
| Tissue Location | According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
References
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Yao T, Song L, Jin J, Cai Y, Takahashi H, Swanson SK, Washburn MP, Florens L, Conaway RC, Cohen RE, Conaway JW. Molecular cell 2008 Sep 31 (6): 909-17. PMID: 18922472
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