|Application ||WB, E|
|Other Accession||NP_005282.1, 2840, 574402 (mouse), 767613 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||40989 Da|
|Other Names||Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, G-protein coupled receptor 17, P2Y-like receptor, R12, GPR17|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR17 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain|
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Provided below are standard protocols that you may find useful for product applications.
GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. Parravicini C, Ranghino G, Abbracchio MP, Fantucci P, BMC bioinformatics 2008 9 : 263. PMID: 18533035
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