|Application ||WB, E|
|Other Accession||NP_005282.1, 2840, 574402 (mouse), 767613 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||40989 Da|
|Other Names||Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, G-protein coupled receptor 17, P2Y-like receptor, R12, GPR17|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR17 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. Parravicini C, Ranghino G, Abbracchio MP, Fantucci P, BMC bioinformatics 2008 9 : 263. PMID: 18533035
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