|Other Accession||NP_065943.2, NP_001096066.1, 113878, 304591 (rat)|
|Predicted||Human, Rat, Cow|
|Calculated MW||67246 Da|
|Other Names||Probable E3 ubiquitin-protein ligase DTX2, 6.3.2.-, Protein deltex-2, Deltex2, hDTX2, RING finger protein 58, DTX2, KIAA1528, RNF58|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DTX2 / Deltext-2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_065943.2; NP_001096066.1). Reported variants NP_001096065.1, NP_065943.2, NP_001096064.1 represent identical protein.
cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. Yi Z, Yi T, Wu Z, DNA sequence : the journal of DNA sequencing and mapping 2006 Jun 17 (3): 175-80. PMID: 17286044
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