|Other Accession||NP_060243.2, NP_001129662.1, 54900|
|Calculated MW||44085 Da|
|Other Names||Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LAX1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein|
|Tissue Location||Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_060243.2; NP_001129662.1).
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. Zhu M, Janssen E, Leung K, Zhang W, The Journal of biological chemistry 2002 Nov 277 (48): 46151-8. PMID: 12359715
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