|Other Accession||NP_612639.2, 129685, 63856 (mouse), 316216 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||34262 Da|
|Other Names||Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, Transcription initiation factor TFIID 43 kDa subunit, TAFII-43, TAFII43, hTAFII43, TAF8, TAFII43, TBN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAF8 / TAFII43 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.|
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Provided below are standard protocols that you may find useful for product applications.
The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Guermah M, Ge K, Chiang CM, Roeder RG, Molecular cell 2003 Oct 12 (4): 991-1001. PMID: 14580349
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