|Application ||WB, E|
|Other Accession||NP_001002244.1, NP_057560.8, 51529|
|Calculated MW||9841 Da|
|Other Names||Anaphase-promoting complex subunit 11, APC11, Cyclosome subunit 11, Hepatocellular carcinoma-associated RING finger protein, ANAPC11|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANAPC11 Antibody (Internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize. Reported variants represent identical protein: NP_057560.8, NP_001002248.1, NP_001002245.1, NP_001002246.1, NP_001002247.1, NP_001002249.1
The RING-H2-finger protein APC11 as a target of hydrogen peroxide. Chang TS, Jeong W, Lee DY, Cho CS, Rhee SG, Free radical biology & medicine 2004 Aug 37 (4): 521-30. PMID: 15256223
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