|Application ||WB, E, EIA|
|Other Accession||NP_006184.2, 5078, 18506 (mouse), 83630 (rat)|
|Calculated MW||37833 Da|
|Other Names||Paired box protein Pax-4, PAX4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.|
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A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome. Haaland WC, Scaduto DI, Maldonado MR, Mansouri DL, Nalini R, Iyer D, Patel S, Guthikonda A, Hampe CS, Balasubramanyam A, Metzker ML, Diabetes care 2009 May 32 (5): 873-7. PMID: 19228875
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