|Other Accession||NP_055332.3, NP_001121632.1, 7342, 22221 (mouse), 301038 (rat)|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||60491 Da|
|Other Names||Upstream-binding protein 1, Transcription factor LBP-1, UBP1, LBP1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBP1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.|
|Tissue Location||Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001121633.1, NP_055332.3.
LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation. Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL, DNA and cell biology 2008 Feb 27 (2): 71-9. PMID: 18004979
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